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recent articles of co amorphous using ball milling method

May 01, 2016 Recent advances in co-amorphous drug formulations ... and ball milling , , , , , , , , , , , , . All of these techniques are attractive as they represent fast and easy ways of (co-)amorphization, and are ideal for screening purposes as only small sample sizes are required. ... the few in vivo studies that have been performed using co-amorphous

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  • High energy ball-milling preparation of Co–B
    High energy ball-milling preparation of Co–B

    Oct 25, 2012 Therefore, it is hopeful to improve the electrochemical properties of Co–B particles by direct high-energy ball-milling method. Until 2008, a nanocrystalline Co–B alloy obtained by ball milling method shown a reversible discharge capacity of around 238 mAh/g at moderately high rate of 130 mA/g . Because the discharge capacity of ball milled Co–B alloy was low, there was much room for making progress on the ball milled Co

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  • Development of a screening method for co
    Development of a screening method for co

    Dec 01, 2016 However, in order to obtain amorphous or co-amorphous samples upon ball milling, the standard milling process may be very time consuming, for example taking up to 60, 90 or 180 min when using an oscillatory ball mill (Alles et al., 2009, L bmann et al., 2012, Jensen et al., 2015a). Furthermore, there has been no rationale so far for the selection of the co-former for a given drug, and selection is often based on a

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  • Ball milling: a green technology for the preparation
    Ball milling: a green technology for the preparation

    Ball milling: a green technology for the preparation and functionalisation of nanocellulose derivatives Carmen C. Piras, a Susana Fernandez-Prieto b and Wim M. De Borggraeve *a Ball milling is a simple, fast, cost-effective green technology with enormous potential

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  • EP0494899A4 - Ball milling apparatus and method, and
    EP0494899A4 - Ball milling apparatus and method, and

    Metallic amorphous materials can be produced using the ball mill of the invention by (a) obtaining amorphous ribbons from a master alloy of the required chemical composition, (b) crystallising the ribbons by annealing at a temperature of about 600 C, then (c) milling the crystallised ribbons in a slight overpressure of dry helium to produce a fully amorphous material

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  • Ball milling: a green technology for the preparation and
    Ball milling: a green technology for the preparation and

    A variety of research articles and reviews has already been published on the use of ball milling in process engineering, organic synthesis and bio- and polymer nanocomposites. 13–17 However, the potential of this technique in the field of cellulose nanoparticles has not been fully explored. The aim of this article

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  • Influence of Preparation Methods on Physicochemical and
    Influence of Preparation Methods on Physicochemical and

    Mar 15, 2019 Methods Preparation of ATV: NRG Co-amorphous Systems Ball Milling (ANBM) The physical mixture of ATV and NRG of a total of 1 g in a molar ratio of 1:1 (ATV 485.46 mg, NRG 505.86 mg) was weighed and subjected to ball milling using a planetary ball mill (Retsch GmbH, Germany, Model No: Retsch PM 100)

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  • Study of Amorphous Compounds Obtained by Ball Milling
    Study of Amorphous Compounds Obtained by Ball Milling

    Amorphous Compounds Obtained by Ball Milling in Si – C – O System 371 Fig. 2 . XRD patterns of (a) the mixture X 1 , (b) the mixture X 2 , and (c) the mixture X 3 with increasing dose D

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  • Co-Amorphous Combination of Nateglinide-Metformin
    Co-Amorphous Combination of Nateglinide-Metformin

    Aug 28, 2015 The aim of the present work was to prepare a co-amorphous mixture (COAM) of Nateglinide and Metformin hydrochloride to enhance the dissolution rate of poorly soluble Nateglinide. Nateglinide (120 mg) and Metformin hydrochloride (500 mg) COAM, as a dose ratio, were prepared by ball-milling technique. COAMs were characterized for saturation solubility, amorphism and physicochemical interactions

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  • [The development of co-amorphous drug systems]
    [The development of co-amorphous drug systems]

    May 01, 2013 Converting two poorly water-soluble crystalline drugs to co-amorphous drug systems by ball milling, quench-cooling, or cryo-milling method can improve stability of the drug, enhance dissolution rates, and reduce adverse reactions of the single drug. Co-amorphous system has been used to solve problems of co-administration of medicines

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  • (PDF) Methods of amorphization and investigation of the
    (PDF) Methods of amorphization and investigation of the

    In this study co-amorphous mixture of curcumin–ascorbic acid (CU:AA) of different molar ratios was prepared using the ball milling method. The solubility and characterization of the mixture were

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  • Preparation and characterization of spray-dried co
    Preparation and characterization of spray-dried co

    Aug 05, 2015 Recently, co-amorphous drug–amino acid mixtures were introduced as a promising alternative to other amorphous stabilization approaches such as the use of polymers to form glass solutions. So far, these co-amorphous mixtures have been mainly prepared via vibrational ball milling on a lab scale

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  • Quantification of Process Induced Disorder in Milled
    Quantification of Process Induced Disorder in Milled

    Feb 16, 2010 2.2.1. Sample preparation by ball milling (cold room) The drugs were milled using an oscillatory ball mill (Mixer Mill MM301, Retsch GmbH & Co., Germany). A central composite face centered design was used for the milling experiments for both compounds. The experimental design was created using MODDE software (version 7, Umetrics AB, Sweden)

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  • Development of a screening method for co-amorphous
    Development of a screening method for co-amorphous

    Aug 13, 2016 In this work, a fast screening process to assess the co-former feasibility in co-amorphous drug-AA blends has been developed on the basis of the amorphization kinetics upon oscillatory ball milling. For this purpose, six model drugs were combined with 20 different AAs and co-milled at an equimolar ratio for different times (1, 5, 15, 30 and 60min)

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  • Characterization of Amorphous and Co-Amorphous
    Characterization of Amorphous and Co-Amorphous

    In this study, spray drying from aqueous solutions, using the surface-active agent sodium lauryl sulfate (SLS) as a solubilizer, was explored as a production method for co-amorphous simvastatin–lysine (SVS-LYS) at 1:1 molar mixtures, which previously have been observed to form a co-amorphous mixture upon ball milling. In addition, a spray-dried formulation of SVS without LYS was prepared

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  • Amorphous anion-rich titanium polysulfides for aluminum
    Amorphous anion-rich titanium polysulfides for aluminum

    The amorphous TiS x (x = 2, 3, and 4) materials were prepared via the high-energy ball milling method at 800 rpm for 24 hours (Fritsch PULVERISETTE 7 premium), in which the mass ratio of zirconia balls (3 mm in diameter) to the raw materials was 10:1

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  • Pharmaceutics | Free Full-Text | Influence of Solvent
    Pharmaceutics | Free Full-Text | Influence of Solvent

    Ball-milling is usually used to prepare co-amorphous drug–amino acid (AA) mixtures. In this study, co-amorphous drug–AA mixtures were produced using spray-drying, a scalable industrially preferred preparation method. The influence of the solvent type and solvent composition was investigated. Mixtures of indomethacin (IND) and each of the three AAs arginine, histidine, and lysine were ball

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  • Rapid mechanochemical synthesis of amorphous alloys:
    Rapid mechanochemical synthesis of amorphous alloys:

    Apr 04, 2017 A rapid method for preparing amorphous alloys has been developed utilizing a SPEX high energy ball mill. Parameters such as ball size, mass of balls and milling time, were systematically optimized to prepare amorphous alloys quickly. Amorphous alloys previously not thought possible to synthesize by means of SPEX milling were made amorphous by the new method. . When applied to the preparation

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